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Article

A systematic review of the A118G (Asn40Asp) variant of OPRM1 in relation to smoking initiation, nicotine dependence and smoking cessation.

Pharmacogenomics - 1 Jun 2012

Verhagen Maaike, Kleinjan Marloes, Engels Rutger Cme

Abstract excerpt

Candidate gene studies on smoking behaviors mainly focused on dopaminergic and serotonergic genes, but genes within the µ-opioid system might also be involved. The A118G variant within the OPRM1 gene has been most often examined in relation to smoking, yielding inconsistent findings. It is largely unknown which of the alleles increases susceptibility for smoking behaviors. The aim of this review was to merge...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22676196
DOI: 10.2217/pgs.12.76

Genes

OPRM1

Provenance

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

A systematic review of the A118G (Asn40Asp) variant of OPRM1 in relation to smoking initiation, nicotine dependence and smoking cessation.PMID 22676196Read ↗

Association of an Asn40Asp (A118G) polymorphism in the mu-opioid receptor gene with substance dependence: a meta-analysis.Semantic proximity Read ↗

Association of A118G polymorphism in the μ-opioid receptor gene with smoking behaviors: a meta-analysis.Semantic proximity Read ↗

μ-Opioid receptor gene (OPRM1) polymorphism A118G: lack of association in Finnish populations with alcohol dependence or alcohol consumption.Semantic proximity Read ↗

Mouse model of OPRM1 (A118G) polymorphism has sex-specific effects on drug-mediated behavior.Semantic proximity Read ↗

Consequences of the 118A&gt;G polymorphism in the OPRM1 gene: translation from bench to bedside?Semantic proximity Read ↗

Possible association between OPRM1 genetic variance at the 118 locus and alcohol dependence in a large treatment sample: relationship to alcohol dependence symptoms.Semantic proximity Read ↗

OPRM1 SNP (A118G): involvement in disease development, treatment response, and animal models.Semantic proximity Read ↗

OPRM1 rs1799971 polymorphism and opioid dependence: evidence from a meta-analysis.Semantic proximity Read ↗

Nonreplication of association between ?-opioid-receptor gene (OPRM1) A118G polymorphism and substance dependenceSemantic proximity Read ↗

Allele frequency and genotype distribution of the opioid receptor μ-1 (OPRM1) A118G polymorphism in the Western Saudi population.Semantic proximity Read ↗

A gene-by-sex interaction for nicotine reward: evidence from humanized mice and epidemiology.Semantic proximity Read ↗

Association of mu-opioid receptor gene polymorphism A118G with alcohol dependence in a Japanese population.Semantic proximity Read ↗

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