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Article

The role of the Asn40Asp polymorphism of the mu opioid receptor gene (OPRM1) on alcoholism etiology and treatment: a critical review.

Alcoholism, clinical and experimental research - 1 Mar 2012

Ray Lara A, Barr Christina S, Blendy Julie A, Oslin David, Goldman David, Anton Raymond F

Abstract excerpt

The endogenous opioid system has been implicated in the pathophysiology of alcoholism as it modulates the neurobehavioral effects of alcohol. A variant in the mu opioid receptor gene (OPRM1), the Asn40Asp polymorphism, has received attention as a functional variant that may influence a host of behavioral phenotypes for alcoholism as well as clinical response to opioid antagonists. This paper will review...

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Identifiers

PMID: 21895723
DOI: 10.1111/j.1530-0277.2011.01633.x
PMCID: PMC3249007

Genes

OPRM1

Provenance

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