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Article

Neurospora mrc1 homologue is involved in replication stability and is required for normal cell growth and chromosome integrity in mus-9 and mus-21 mutants.

Fungal genetics and biology : FG & B - 1 Apr 2012

Wakabayashi Michiyoshi, Saijyou Nobuyuki, Hatakeyama Shin, Inoue Hirokazu, Tanaka Shuuitsu

Abstract excerpt

Stalled replication forks easily collapse and such structures can induce DNA strand breaks or toxic recombination products. Therefore, factors involved in stabilization of replication should be important for genome integrity. In our previous study, loss of both ATM and ATR homologues was shown to...

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Source

Identifiers

PMID: 22395065
DOI: 10.1016/j.fgb.2012.02.007

Genes

ATM
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22395065-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Neurospora mrc1 homologue is involved in replication stability and is required for normal cell growth and chromosome integrity in mus-9 and mus-21 mutants.PMID 22395065Read ↗

ATM and ATR homologes of Neurospora crassa are essential for normal cell growth and maintenance of chromosome integrity.Semantic proximity Read ↗

Genetic analysis of CHK1 and CHK2 homologues revealed a unique cross talk between ATM and ATR pathways in Neurospora crassa.Semantic proximity Read ↗

Continued DNA synthesis in replication checkpoint mutants leads to fork collapse.Semantic proximity Read ↗

Mrc1 is required for normal progression of replication forks throughout chromatin in S. cerevisiae.Semantic proximity Read ↗

mus-52 disruption and metabolic regulation in Neurospora crassa: Transcriptional responses to extracellular phosphate availability.Semantic proximity Read ↗

Genetic and molecular characterization of Neurospora crassa mus-23: a gene involved in recombinational repair.Semantic proximity Read ↗

The Replisome-Coupled E3 Ubiquitin Ligase Rtt101Mms22 Counteracts Mrc1 Function to Tolerate Genotoxic Stress.Semantic proximity Read ↗

Mms1-Mms22 complex protects genome integrity in Schizosaccharomyces pombe.Semantic proximity Read ↗

Srs2 and RecQ homologs cooperate in mei-3-mediated homologous recombination repair of Neurospora crassa.Semantic proximity Read ↗

The direct binding of Mrc1, a checkpoint mediator, to Mcm6, a replication helicase, is essential for the replication checkpoint against methyl methanesulfonate-induced stress.Semantic proximity Read ↗

A mutation in DNA polymerase γ harbors a shortened lifespan and high sensitivity to mutagens in the filamentous fungus Neurospora crassa.Semantic proximity Read ↗

Replication checkpoint kinase Cds1 regulates Mus81 to preserve genome integrity during replication stress.Semantic proximity Read ↗

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