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A mutation in DNA polymerase γ harbors a shortened lifespan and high sensitivity to mutagens in the filamentous fungus Neurospora crassa.

Genetics - 5 Feb 2025

Yoshihara Ryouhei, Shimakura Yuzuki, Kitamura Satoshi, Satoh Katsuya, Sato Manami, Aono Taketo, Akiyama Yu, Hatakeyama Shin, Tanaka Shuuitsu

Abstract excerpt

Hyphal elongation is the vegetative growth of filamentous fungi, and many species continuously elongate their hyphal tips over long periods. The details of the mechanisms for maintaining continuous growth are not yet clear. A novel short lifespan mutant of N. crassa that ceases hyphal elongation early was screened and analyzed to better understand the mechanisms for maintaining hyphal elongation in filamentous...

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PMID: 39611774
DOI: 10.1093/genetics/iyae201

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MIP

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