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Article

Condensin IDC has a functional ATPase that is required for X-Chromosome dosage compensation in C. elegans.

Genetics - 6 May 2026

Chawla Bahaar, Jatia Suchi, Sloan Dillon, Eduful Joshua, Mendoza Hector, McClear Christian A, Tran Jeannine, Csankovszki Gyorgyi

Abstract excerpt

Dosage compensation (DC) in Caenorhabditis elegans utilizes a condensin complex that resembles mitotic condensins but differs by 1 subunit, DPY-27. DPY-27 replaces SMC-4, one of the structural maintenance of chromosome (SMC) proteins that is responsible for hydrolyzing ATP, required for the condensation of DNA and other mitotic condensin functions. To understand whether the ATPase function is required in DC, we...

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Identifiers

PMID: 41841690
DOI: 10.1093/genetics/iyag072
PMCID: PMC13147532

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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