Article
Muscarinic M1 receptor sequence: preliminary studies on its effects on cognition and expression.
Schizophrenia research - 1 Jun 2012
Scarr Elizabeth, Sundram Suresh, Deljo Azita, Cowie Tiffany Francis, Gibbons Andrew Stuart, Juzva Susan, Mackinnon Andrew, Wood Stephen J, Testa Renee, Pantelis Christos, Dean Brian
Abstract excerpt
It has been reported that people with schizophrenia who are homozygous at the c.267C>A single nucleotide polymorphism of the cholinergic muscarinic M1 receptor (CHRM1) perform less well on the Wisconsin Card Sorting Test than those who are heterozygous. We investigated whether CHRM1 sequence is associated with impaired executive function, a common problem in schizophrenia. We sequenced the CHRM1 using peripheral...
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