The relationship between plasma levels of clozapine and N-desmethyclozapine as well as M1 receptor polymorphism with cognitive functioning and associated cortical activity in schizophrenia.

doi:10.1016/j.pscychresns.2020.111128

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Article

The relationship between plasma levels of clozapine and N-desmethyclozapine as well as M1 receptor polymorphism with cognitive functioning and associated cortical activity in schizophrenia.

Psychiatry research. Neuroimaging - 30 Sept 2020

Kır Yağmur, Baskak Bora, Kuşman Adnan, Sayar-Akaslan Damla, Özdemir Fezile, Sedes-Baskak Nilay, Süzen Halit Sinan, Baran Zeynel

Abstract excerpt

Studies that examined the effect of clozapine on cognitive functions in schizophrenia provided contradictory results. N-desmethylclozapine (NDMC) is the major metabolite of clozapine and have procognitive effects via agonistic activity in the M1 cholinergic receptors. The rs2067477 polymorphism in the M1 receptors may play role in cognitive profile in schizophrenia. We investigated the association of plasma...

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PMID: 32593951
DOI: 10.1016/j.pscychresns.2020.111128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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