Article
Single nucleotide polymorphisms of the human M1 muscarinic acetylcholine receptor gene.
AAPS pharmSci - 1 Jan 2001
Lucas J L, DeYoung J A, Sadee W
Abstract excerpt
The gene encoding the human muscarinic receptor, type 1 (CHRM1), was genotyped from 245 samples of the Coriell Collection (Coriell Institute for Medical Research, Camden, NJ). Fifteen single nucleotide polymorphisms (SNPs) were discovered, 9 of which are located in the coding region of the receptor. Of these, 8 represent synonymous SNPs, indicating that CHRM1 is highly conserved in humans. Only a single allele...
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