Article

Muscarinic receptors downregulation is associated with increased IL6 expression in brain samples of individuals with schizophrenia

2025-05-16

Abstract excerpt

Acetylcholine plays a role in the immune system with notable anti-inflammatory properties. Xanomeline, a muscarinic acetylcholine receptor agonist, was recently approved for schizophrenia, marking the first therapy of its kind. Evidence suggests two molecular subtypes of schizophrenia: one characterized by reduced muscarinic receptor expression (muscarinic receptor-deficit schizophrenia, MRDS), and another marked...

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Literature Corpus work: 096fd641-df27-594b-b12b-eb5b32ad475f
DOI: 10.22541/au.174736650.05448372/v1

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