Article
Polymorphisms of the cannabinoid 1 receptor gene and cognitive impairment in multiple sclerosis.
Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Mar 2008
Woolmore Ja, Stone Mj, Holley Sl, Jenkinson Pm, Ike A, Jones Pw, Fryer Aa, Strange Rc, Stephens R, Langdon Dw, Hawkins Cp
Abstract excerpt
Cognitive impairment occurs in 45-65% of multiple sclerosis (MS) patients. The cannabinoid system may potentially be neuroprotective in MS. We examined the relationship between polymorphisms of the CNR1 gene and neuropsychological outcome in MS using a test and confirmatory sample of patients. One hundred and ninety-four MS patients were assessed over five key areas of neuropsychological function, which are most...
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