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Article

Protein Gq modulates termination of phototransduction and prevents retinal degeneration.

The Journal of biological chemistry - 20 Apr 2012

Hu Wen, Wan Didi, Yu Xiaoming, Cao Jinguo, Guo Peiyi, Li Hong-Sheng, Han Junhai

Abstract excerpt

Appropriate termination of the phototransduction cascade is critical for photoreceptors to achieve high temporal resolution and to prevent excessive Ca(2+)-induced cell toxicity. Using a genetic screen to identify defective photoresponse mutants in Drosophila, we isolated and identified a novel Gα(q) mutant allele, which has defects in both activation and deactivation. We revealed that G(q) modulates the...

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Share to GTP-Binding Protein alpha Subunits, Gq-G11

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Light Signal Transduction

Share to Photoreceptor Cells, Invertebrate

Share to Receptors, G-Protein-Coupled

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Source

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Identifiers

PMID: 22389492
DOI: 10.1074/jbc.M112.339895
PMCID: PMC3340195

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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