Article
Gq alpha protein function in vivo: genetic dissection of its role in photoreceptor cell physiology.
Neuron - 1 Oct 1995
Scott K, Becker A, Sun Y, Hardy R, Zuker C
Abstract excerpt
Heterotrimeric G proteins mediate a variety of signaling processes by coupling seven-transmembrane receptors to intracellular effector molecules. The Drosophila phototransduction cascade is a G protein-coupled signaling cascade that utilizes a phospholipase C (PLC beta) effector. PLC beta has been shown to be activated by Gq alpha in reconstituted systems. To determine whether a Gq-like protein couples rhodopsin...
Topics
- Amino Acid Sequence
- Animals
- Animals, Genetically Modified
- Drosophila
- Electrophysiology
- GTP-Binding Proteins
- Light
- Macromolecular Substances
- Molecular Sequence Data
- Mutation
- Patch-Clamp Techniques