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Article

Arrestin function in inactivation of G protein-coupled receptor rhodopsin in vivo.

Science (New York, N.Y.) - 25 Jun 1993

Dolph P J, Ranganathan R, Colley N J, Hardy R W, Socolich M, Zuker C S

Abstract excerpt

Arrestins have been implicated in the regulation of many G protein-coupled receptor signaling cascades. Mutations in two Drosophila photoreceptor-specific arrestin genes, arrestin 1 and arrestin 2, were generated. Analysis of the light response in these mutants shows that the Arr1 and Arr2 proteins are mediators of rhodopsin inactivation and are essential for the termination of the phototransduction cascade in...

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Identifiers

PMID: 8316831
DOI: 10.1126/science.8316831

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