Article
Ins(1,4,5)P3 3-kinase-A overexpression induces cytoskeletal reorganization via a kinase-independent mechanism.
The Biochemical journal - 15 Sept 2008
Windhorst Sabine, Blechner Christine, Lin Hong-Ying, Elling Christian, Nalaskowski Marcus, Kirchberger Tanja, Guse Andreas H, Mayr Georg W
Abstract excerpt
In the present study, effects of increased IP3K-A [Ins(1,4,5)P(3) 3-kinase-A] expression were analysed. H1299 cells overexpressing IP3K-A formed branching protrusions, and under three-dimensional culture conditions, they exhibited a motile fibroblast-like morphology. They lost the ability to form actin stress fibres and showed increased invasive migration in vitro. Furthermore, expression levels of the...
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