Article
Regulation of neurite growth by spontaneous Ca2+ oscillations in astrocytes.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Aug 2007
Kanemaru Kazunori, Okubo Yohei, Hirose Kenzo, Iino Masamitsu
Abstract excerpt
Astrocytes play a pivotal role in the regulation of neurite growth, but the intracellular signaling mechanism in astrocytes that mediates this regulation remains unclarified. We studied the relationship between spontaneous Ca(2+) oscillations in astrocytes and the astrocyte-mediated neurite growth. We generated Ca(2+) signal-deficient astrocytes in which spontaneous Ca(2+) oscillations were abolished by a chronic...
Topics
- Analysis of Variance
- Animals
- Astrocytes
- Calcium
- Calcium Signaling
- Cells, Cultured
- Coculture Techniques
- Drug Interactions
- Embryo, Mammalian
- Enzyme Inhibitors
- Glial Fibrillary Acidic Protein
- Growth Cones
- Hippocampus