Article
Regulation of neurite growth by spontaneous Ca2+ oscillations in astrocytes.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Aug 2007
Kanemaru Kazunori, Okubo Yohei, Hirose Kenzo, Iino Masamitsu
Abstract excerpt
Astrocytes play a pivotal role in the regulation of neurite growth, but the intracellular signaling mechanism in astrocytes that mediates this regulation remains unclarified. We studied the relationship between spontaneous Ca(2+) oscillations in astrocytes and the astrocyte-mediated neurite growth. We generated Ca(2+) signal-deficient astrocytes in which spontaneous Ca(2+) oscillations were abolished by a chronic...
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