Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multiple ganciclovir-resistant strains in a newborn with symptomatic congenital human cytomegalovirus infection.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 May 2012

Campanini Giulia, Zavattoni Maurizio, Cristina Emilio, Gazzolo Diego, Stronati Mauro, Baldanti Fausto

Abstract excerpt

A case of human cytomegalovirus (HCMV) drug-resistance in a congenitally infected newborn is described. Unusual aspects of this case include: (i) the detection of an extremely complex virus population, composed of a mixture of wild-type (wt) and multiple mutant ganciclovir (GCV) and valganciclovir (val-GCV) resistant strains carrying a variety of known mutations in UL97; (ii) the identification of novel UL97...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Viral
Share to Antiviral Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Coinfection

Share to Cytomegalovirus

Share to Cytomegalovirus Infections

Share to Drug Resistance, Viral

Share to Ganciclovir

Share to Phosphotransferases (Alcohol Group Acceptor)

Source

Identifiers

PMID: 22381918
DOI: 10.1016/j.jcv.2012.01.020

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiple ganciclovir-resistant strains in a newborn with symptomatic congenital human cytomegalovirus infection.PMID 22381918Read ↗

Early emergence of ganciclovir-resistant human cytomegalovirus strains in children with primary combined immunodeficiency.Semantic proximity Read ↗

Dynamics of the emergence of a human cytomegalovirus UL97 mutant strain conferring ganciclovir resistance in a pediatric stem-cell transplant recipient.Semantic proximity Read ↗

Pyrosequencing allows the detection of emergent ganciclovir resistance mutations after HCMV infection.Semantic proximity Read ↗

Detection of antiviral drug resistance in patients with congenital cytomegalovirus infection using long-read sequencing: a retrospective observational study.Semantic proximity Read ↗

Identification of resistance-associated HCMV UL97- and UL54-mutations and a UL97-polymporphism with impact on phenotypic drug-resistance.Semantic proximity Read ↗

Single and multiple mutations in the human cytomegalovirus UL97 gene and their relationship to the enzymatic activity of UL97 kinase for ganciclovir phosphorylation.Semantic proximity Read ↗

A new tool linking human cytomegalovirus drug resistance mutations to resistance phenotypes.Semantic proximity Read ↗

Onset of valganciclovir resistance in two infants with congenital cytomegalovirus infection.Semantic proximity Read ↗

The genetic basis of human cytomegalovirus resistance and current trends in antiviral resistance analysis.Semantic proximity Read ↗

Cytomegalovirus antiviral resistance associated with treatment induced UL97 (protein kinase) and UL54 (DNA polymerase) mutations.Semantic proximity Read ↗

Identification of newly detected, drug-related HCMV UL97- and UL54-mutations using a modified plaque reduction assay.Semantic proximity Read ↗

Mutations in human cytomegalovirus UL97 gene confer clinical resistance to ganciclovir and can be detected directly in patient plasma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.