Article
Early emergence of ganciclovir-resistant human cytomegalovirus strains in children with primary combined immunodeficiency.
The Journal of infectious diseases - 1 Aug 1998
Wolf D G, Yaniv I, Honigman A, Kassis I, Schonfeld T, Ashkenazi S
Abstract excerpt
Children with primary combined immunodeficiency (CID) and human cytomegalovirus (HCMV) infection often deteriorate despite antiviral therapy. In this study, the emergence of ganciclovir-resistant strains was examined in 6 children with CID and HCMV infection, using sequence analysis of the HCMV U...
Topics
- Bone Marrow Transplantation
- Child, Preschool
- Cytomegalovirus
- Cytomegalovirus Infections
- Drug Resistance, Microbial
- Ganciclovir
- Genotype
- Humans
- Immunologic Deficiency Syndromes
- Infant
- Phosphotransferases (Alcohol Group Acceptor)
- Point Mutation
- Viral Envelope Proteins