Article
Dynamics of the emergence of a human cytomegalovirus UL97 mutant strain conferring ganciclovir resistance in a pediatric stem-cell transplant recipient.
The Journal of molecular diagnostics : JMD - 1 Jul 2009
Göhring Katharina, Feuchtinger Tobias, Mikeler Elfriede, Lang Peter, Jahn Gerhard, Handgretinger Rupert, Hamprecht Klaus
Abstract excerpt
Stem-cell transplant recipients are at risk of developing ganciclovir-resistant human cytomegalovirus (HCMV) infection caused by mutations in the viral UL97 gene. Knowledge of the relative proportions of coexisting HCMV wild-type and mutant strains may contribute to a better understanding of the dynamics of in vivo mutant strain selection under ganciclovir. Currently, genotype resistance screening for UL97 is...
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