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Article

CD86 is expressed on murine hematopoietic stem cells and denotes lymphopoietic potential.

Blood - 24 May 2012

Shimazu Tomoyuki, Iida Ryuji, Zhang Qingzhao, Welner Robert S, Medina Kay L, Alberola-Lla José, Kincade Paul W

Abstract excerpt

A unique subset of CD86(-) HSCs was previously discovered in mice that were old or chronically stimulated with lipopolysaccharide. Functionally defective HSCs were also present in those animals, and we now show that CD86(-) CD150(+) CD48(-) HSCs from normal adult mice are particularly poor at restoring the adaptive immune system. Levels of the marker are high on all progenitors with lymphopoietic potential, and...

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Identifiers

PMID: 22371880
DOI: 10.1182/blood-2011-10-388736
PMCID: PMC3367893

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