Article
How to measure the immunosuppressive activity of MDSC: assays, problems and potential solutions.
Cancer immunology, immunotherapy : CII - 1 Apr 2019
Bruger Annika M, Dorhoi Anca, Esendagli Gunes, Barczyk-Kahlert Katarzyna, van der Bruggen Pierre, Lipoldova Marie, Perecko Tomas, Santibanez Juan, Saraiva Margarida, Van Ginderachter Jo A, Brandau Sven
Abstract excerpt
Myeloid-derived suppressor cells (MDSC) are a heterogeneous group of mononuclear and polymorphonuclear myeloid cells, which are present at very low numbers in healthy subjects, but can expand substantially under disease conditions. Depending on disease type and stage, MDSC comprise varying amounts of immature and mature differentiation stages of myeloid cells. Validated unique phenotypic markers for MDSC are...
Topics
- Animals
- Biomarkers
- Cell Communication
- Cytokines
- Humans
- Immunomodulation
- Immunophenotyping
- Lymphocyte Activation
- Myeloid-Derived Suppressor Cells
- Phenotype