Article
Dormant and self-renewing hematopoietic stem cells and their niches.
Annals of the New York Academy of Sciences - 1 Jun 2007
Wilson Anne, Oser Gabriela M, Jaworski Maike, Blanco-Bose William E, Laurenti Elisa, Adolphe Christelle, Essers Marieke A, Macdonald H Robson, Trumpp Andreas
Abstract excerpt
In the mouse, over the last 20 years, a set of cell-surface markers and activities have been identified, enabling the isolation of bone marrow (BM) populations highly enriched in hematopoietic stem cells (HSCs). These HSCs have the ability to generate multiple lineages and are capable of long-term self-renewal activity such that they are able to reconstitute and maintain a functional hematopoietic system after...
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