Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Monocytes derived from humanized neonatal NOD/SCID/IL2Rγ(null) mice are phenotypically immature and exhibit functional impairments.

Human immunology - 1 Apr 2012

Gille Christian, Orlikowsky Thorsten W, Spring Baerbel, Hartwig Udo F, Wilhelm Ayline, Wirth Andreas, Goecke Barbara, Handgretinger Rupert, Poets Christian F, André Maya C

Abstract excerpt

Trials of immune-modulating drugs in septic patients have mostly failed to demonstrate clinical efficacy. Thus, we sought to generate a surrogate model of myelomonocytic lineage differentiation that would potentially allow sepsis induction and preclinical testing of anti-inflammatory drugs. Compa...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Immunophenotyping
Share to Inflammation Mediators

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Interleukin Receptor Common gamma Subunit

Share to Lipopolysaccharide Receptors

Share to Mice, Inbred NOD

Share to Mice, SCID

Share to Monocytes

Share to Phagocytosis

Source

Identifiers

PMID: 22330087
DOI: 10.1016/j.humimm.2012.01.006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22330087-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Monocytes derived from humanized neonatal NOD/SCID/IL2Rγ(null) mice are phenotypically immature and exhibit functional impairments.PMID 22330087Read ↗

Granulocytic myeloid-derived suppressor cells from human cord blood modulate T-helper cell response towards an anti-inflammatory phenotype.Semantic proximity Read ↗

An impaired inflammatory cytokine response to gram-negative LPS in human neonates is associated with the defective TLR-mediated signaling pathway.Semantic proximity Read ↗

Neonatal platelets differentiate monocytes to a myeloid-derived suppressor cell phenotype.Semantic proximity Read ↗

Single-cell transcriptomic analysis reveals heterogeneous features of myeloid-derived suppressor cells in newbornsSemantic proximity Read ↗

The phenotype and function of preterm infant monocytes: implications for susceptibility to infectionSemantic proximity Read ↗

Transcriptional pathways of terminal differentiation in high- and low-density blood granulocytes in sepsisSemantic proximity Read ↗

Long-term immune reprogramming of classical monocytes with altered ontogeny mediates enhanced lung injury in sepsis survivorsSemantic proximity Read ↗

Phenotypic differences in leucocyte populations among healthy preterm and full-term newborns.Semantic proximity Read ↗

Sepsis Inflammation Impairs the Generation of Functional Dendritic Cells by Targeting Their Progenitors.Semantic proximity Read ↗

Distinct phenotypic features of neonatal murine macrophages.Semantic proximity Read ↗

NOD/LtSz-Rag1nullPfpnull mice: a new model system with increased levels of human peripheral leukocyte and hematopoietic stem-cell engraftment.Semantic proximity Read ↗

Blood plasmacytoid dendritic cell responses to CpG oligodeoxynucleotides are impaired in human newborns.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.