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Article

Reducing functionally defective old HSCs alleviates aging-related phenotypes in old recipient mice.

Cell research - 1 Jan 2025

Wang Yuting, Zhang Wenhao, Zhang Chao, Van Hoang Q Tran, Seino Takashi, Zhang Yi

Abstract excerpt

Aging is a process accompanied by functional decline in tissues and organs with great social and medical consequences. Developing effective anti-aging strategies is of great significance. In this study, we demonstrated that transplantation of young hematopoietic stem cells (HSCs) into old mice can mitigate aging phenotypes, underscoring the crucial role of HSCs in the aging process. Through comprehensive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39743633
DOI: 10.1038/s41422-024-01057-5
PMCID: PMC11701126

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