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Article

Plasma folate, methylenetetrahydrofolate reductase (MTHFR), and colorectal cancer risk in three large nested case-control studies.

Cancer causes & control : CCC - 1 Apr 2012

Lee Jung Eun, Wei Esther K, Fuchs Charles S, Hunter David J, Lee I-Min, Selhub Jacob, Stampfer Meir J, Willett Walter C, Ma Jing, Giovannucci Edward

Abstract excerpt

Few prospective studies have examined the associations between blood levels of folate, in conjunction with methylenetetrahydrofolate reductase (MTHFR) polymorphisms, and colorectal cancer. We evaluated the associations between plasma folate, MTHFR C677T, and A1298C, and colorectal cancer in three large prospective studies: the Nurses' Health Study, the Health Professionals Follow-up Study, and the Physicians'...

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Source

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Identifiers

PMID: 22367721
DOI: 10.1007/s10552-012-9911-3
PMCID: PMC3721151

Genes

MTHFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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