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Article

Unmetabolized Folic Acid in Prediagnostic Plasma and the Risk of Colorectal Cancer.

Journal of the National Cancer Institute - 1 Dec 2015

Cho Eunyoung, Zhang Xuehong, Townsend Mary K, Selhub Jacob, Paul Ligi, Rosner Bernard, Fuchs Charles S, Willett Walter C, Giovannucci Edward L

Abstract excerpt

Higher folate has been associated with a reduced colorectal cancer (CRC) risk, but excessive folate may promote tumor progression. The role of unmetabolized folic acid (UFA) from high folic acid consumption in carcinogenesis is largely unexplored. We evaluated prediagnostic plasma levels of UFA in relation to CRC risk in nested case-control studies (618 CRC case patients and 1207 matched control) with blood...

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Identifiers

PMID: 26376686
DOI: 10.1093/jnci/djv260
PMCID: PMC4715248

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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