Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DRB1*03:01 haplotypes: differential contribution to multiple sclerosis risk and specific association with the presence of intrathecal IgM bands.

PloS one - 1 Jan 2012

de la Concha Emilio G, Cavanillas María L, Cénit M Carmen, Urcelay Elena, Arroyo Rafael, Fernández Óscar, Álvarez-Cermeño José C, Leyva Laura, Villar Luisa M, Núñez Concepción

Abstract excerpt

BACKGROUND: Multiple sclerosis (MS) is a multifactorial disease with a genetic basis. The strongest associations with the disease lie in the Human Leukocyte Antigen (HLA) region. However, except for the DRB1*15:01 allele, the main risk factor associated to MS so far, no consistent effect has been described for any other variant. One example is HLA-DRB1*03:01, with a heterogeneous effect across populations and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Case-Control Studies
Share to Genetic Association Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Haplotypes

Share to HLA-DRB1 Chains

Share to Immunoglobulin M

Share to Multiple Sclerosis

Share to Risk Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 22363536
DOI: 10.1371/journal.pone.0031018
PMCID: PMC3281895

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DRB1*03:01 haplotypes: differential contribution to multiple sclerosis risk and specific association with the presence of intrathecal IgM bands.PMID 22363536Read ↗

The Involvement of HLA Class II Alleles in Multiple Sclerosis: A Systematic Review with Meta-analysis.Semantic proximity Read ↗

Association of genetic markers with CSF oligoclonal bands in multiple sclerosis patients.Semantic proximity Read ↗

High‐resolution HLA class II sequencing of Swedish multiple sclerosis patientsSemantic proximity Read ↗

Immunogenetic Epidemiology of Multiple Sclerosis in 14 Continental Western European CountriesSemantic proximity Read ↗

Disease-Associated HLA Alleles and Haplotypes in Multiple Sclerosis: Insights from an Albanian Case–Control StudySemantic proximity Read ↗

Deconstruction of HLA-DRB1*04:01:01 and HLA-DRB1*15:01:01 class II haplotypes using next-generation sequencing in European-Americans with multiple sclerosisSemantic proximity Read ↗

Burden of risk variants correlates with phenotype of multiple sclerosis.Semantic proximity Read ↗

High resolution HLA analysis reveals independent class I haplotypes and amino-acid motifs protective for multiple sclerosis.Semantic proximity Read ↗

A study of the HLA-DR region in clinical subgroups of multiple sclerosis and its influence on prognosis.Semantic proximity Read ↗

Risk HLA Variants Affect the T-Cell Repertoire in Multiple SclerosisSemantic proximity Read ↗

The HLA DRB1*03:01 allele is associated with NMO regardless of the NMO-IgG status in Brazilian patients from Rio de Janeiro.Semantic proximity Read ↗

HLA (A-B-C and -DRB1) alleles and brain MRI changes in multiple sclerosis: a longitudinal study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.