Article
Association of genetic markers with CSF oligoclonal bands in multiple sclerosis patients.
PloS one - 1 Jan 2013
Leone Maurizio A, Barizzone Nadia, Esposito Federica, Lucenti Ausiliatrice, Harbo Hanne F, Goris An, Kockum Ingrid, Oturai Annette Bang, Celius Elisabeth Gulowsen, Mero Inger L, Dubois Bénédicte, Olsson Tomas, Søndergaard Helle Bach, Cusi Daniele, Lupoli Sara, Andreassen Bettina Kulle, Myhr Kjell-Morten, Guerini Franca R, Comi Giancarlo, Martinelli-Boneschi Filippo, D'Alfonso Sandra
Abstract excerpt
OBJECTIVE: to explore the association between genetic markers and Oligoclonal Bands (OCB) in the Cerebro Spinal Fluid (CSF) of Italian Multiple Sclerosis patients. METHODS: We genotyped 1115 Italian patients for HLA-DRB1*15 and HLA-A*02. In a subset of 925 patients we tested association with 52 non-HLA SNPs associated with MS susceptibility and we calculated a weighted Genetic Risk Score. Finally, we performed a...
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