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Article

Burden of risk variants correlates with phenotype of multiple sclerosis.

Multiple sclerosis (Houndmills, Basingstoke, England) - 1 Nov 2015

Hilven Kelly, Patsopoulos Nikolaos A, Dubois Bénédicte, Goris An

Abstract excerpt

BACKGROUND: More than 100 common variants underlying multiple sclerosis (MS) susceptibility have been identified, but their effect on disease phenotype is still largely unknown. OBJECTIVE: The objective of this paper is to assess whether the cumulative genetic risk score of currently known susceptibility variants affects clinical presentation. METHODS: A cumulative genetic risk score was based on four human...

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PMID: 25948629
DOI: 10.1177/1352458514568174

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