Epigenetic control of smooth muscle cell differentiation and phenotypic switching in vascular development and disease.

doi:10.1146/annurev-physiol-012110-142315

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Article

Epigenetic control of smooth muscle cell differentiation and phenotypic switching in vascular development and disease.

Annual review of physiology - 1 Jan 2012

Alexander Matthew R, Owens Gary K

Abstract excerpt

The vascular smooth muscle cell (SMC) in adult animals is a highly specialized cell whose principal function is contraction. However, this cell displays remarkable plasticity and can undergo profound changes in phenotype during repair of vascular injury, during remodeling in response to altered blood flow, or in various disease states. There has been extensive progress in recent years in our understanding of the...

Topics

Animals
Arteries
Atherosclerosis
Blood Vessels
Cell Differentiation
Chromatin
Environment
Epigenesis, Genetic
Epigenomics
Gene Expression Regulation
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mesenchymal Stem Cells

Muscle, Smooth, Vascular

Myocytes, Smooth Muscle

Phenotype

Pluripotent Stem Cells

Vascular Diseases

Source

Open in PubMed

Identifiers

PMID: 22017177
DOI: 10.1146/annurev-physiol-012110-142315

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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