Article
astray, a zebrafish roundabout homolog required for retinal axon guidance.
Science (New York, N.Y.) - 20 Apr 2001
Fricke C, Lee J S, Geiger-Rudolph S, Bonhoeffer F, Chien C B
Abstract excerpt
As growing retinotectal axons navigate from the eye to the tectum, they sense guidance molecules distributed along the optic pathway. Mutations in the zebrafish astray gene severely disrupt retinal axon guidance, causing anterior-posterior pathfinding defects, excessive midline crossing, and defasciculation of the retinal projection. Eye transplantation experiments show that astray function is required in the...
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