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Article

C. elegans AP-2 and retromer control Wnt signaling by regulating mig-14/Wntless.

Developmental cell - 1 Jan 2008

Pan Chun-Liang, Baum Paul D, Gu Mingyu, Jorgensen Erik M, Clark Scott G, Garriga Gian

Abstract excerpt

While endocytosis can regulate morphogen distribution, its precise role in shaping these gradients is unclear. Even more enigmatic is the role of retromer, a complex that shuttles proteins between endosomes and the Golgi apparatus, in Wnt gradient formation. Here we report that DPY-23, the C. elegans mu subunit of the clathrin adaptor AP-2 that mediates the endocytosis of membrane proteins, regulates Wnt...

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Identifiers

PMID: 18160346
DOI: 10.1016/j.devcel.2007.12.001
PMCID: PMC2709403

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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