Article
Isotyping the human TOMM40 variable-length polymorphism by gene amplification and restriction digest.
Current Alzheimer research - 1 Dec 2012
Greco Steven J, Hamzelou Ashkan, Johnston Jane M, Richardson Sandy, Smith Mark A, Perry George, Ashford J Wesson, Tezapsidis Nikolaos
Abstract excerpt
Recent studies have shown that the translocase of outer mitochondrial membrane 40 homolog (TOMM40) contains a polymorphic poly-T variant, the long variant of which is associated with an increase in AD incidence among APOE 3 carriers. Current methods to isotype the poly-T region rely on long PCR, subcloning and sequencing to distinguish among the allelic variants. While such methods are extremely accurate as well...
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