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Article

Impaired cleavage of preproinsulin signal peptide linked to autosomal-dominant diabetes.

Diabetes - 1 Apr 2012

Liu Ming, Lara-Lemus Roberto, Shan Shu-ou, Wright Jordan, Haataja Leena, Barbetti Fabrizio, Guo Huan, Larkin Dennis, Arvan Peter

Abstract excerpt

Recently, missense mutations upstream of preproinsulin's signal peptide (SP) cleavage site were reported to cause mutant INS gene-induced diabetes of youth (MIDY). Our objective was to understand the molecular pathogenesis using metabolic labeling and assays of proinsulin export and insulin and C-peptide production to examine the earliest events of insulin biosynthesis, highlighting molecular mechanisms...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22357960
DOI: 10.2337/db11-0878
PMCID: PMC3314357

Genes

INS

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