Article
Biological behaviors of mutant proinsulin contribute to the phenotypic spectrum of diabetes associated with insulin gene mutations.
Molecular and cellular endocrinology - 1 Dec 2020
Wang Heting, Saint-Martin Cécile, Xu Jialu, Ding Li, Wang Ruodan, Feng Wenli, Liu Ming, Shu Hua, Fan Zhenqian, Haataja Leena, Arvan Peter, Bellanné-Chantelot Christine, Cui Jingqiu, Huang Yumeng
Abstract excerpt
Insulin gene mutation is the second most common cause of neonatal diabetes (NDM). It is also one of the genes involved in maturity-onset diabetes of the young (MODY). We aim to investigate molecular behaviors of different INS gene variants that may correlate with the clinical spectrum of diabetes phenotypes. In this study, we concentrated on two previously uncharacterized MODY-causing mutants,...
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