Article

Distinct states of proinsulin misfolding in MIDY

2021-05-10

Abstract excerpt

A precondition for efficient proinsulin export from the endoplasmic reticulum (ER) is that proinsulin meets ER quality control folding requirements, including formation of the Cys(B19)-Cys(A20) “interchain” disulfide bond, facilitating formation of the Cys(B7)-Cys(A7) bridge. The third proinsulin disulfide, Cys(A6)-Cys(A11), is not required for anterograde trafficking, i.e., a “lose-A6/A11” mutant [Cys(A6), Cys(A1...

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Literature Corpus work: deb4d569-d949-5e25-8697-3d1b3bb0ae9b
DOI: 10.1101/2021.05.10.442447

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