Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chaperone-Driven Degradation of a Misfolded Proinsulin Mutant in Parallel With Restoration of Wild-Type Insulin Secretion.

Diabetes - 1 Mar 2017

Cunningham Corey N, He Kaiyu, Arunagiri Anoop, Paton Adrienne W, Paton James C, Arvan Peter, Tsai Billy

Abstract excerpt

In heterozygous patients with a diabetic syndrome called mutant INS gene-induced diabetes of youth (MIDY), there is decreased insulin secretion when mutant proinsulin expression prevents wild-type (WT) proinsulin from exiting the endoplasmic reticulum (ER), which is essential for insulin production. Our previous results revealed that mutant Akita proinsulin is triaged by ER-associated degradation (ERAD). We now...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Diabetes Mellitus
Share to Endoplasmic Reticulum-Associated Degradation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knockdown Techniques

Share to HSP70 Heat-Shock Proteins

Share to Insulin-Secreting Cells

Share to Insulin Secretion

Share to Molecular Chaperones

Share to Proinsulin

Source

Open in PubMed Open full text

Identifiers

PMID: 28028074
DOI: 10.2337/db16-1338
PMCID: PMC5319713

Genes

INS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chaperone-Driven Degradation of a Misfolded Proinsulin Mutant in Parallel With Restoration of Wild-Type Insulin Secretion.PMID 28028074Read ↗

Proinsulin misfolding and diabetes: mutant INS gene-induced diabetes of youth.Semantic proximity Read ↗

Misfolded proinsulin in the endoplasmic reticulum during development of beta cell failure in diabetes.Semantic proximity Read ↗

Mutant INS-gene induced diabetes of youth: proinsulin cysteine residues impose dominant-negative inhibition on wild-type proinsulin transport.Semantic proximity Read ↗

Role of Proinsulin Self-Association in Mutant <i>INS</i> gene-induced Diabetes of YouthSemantic proximity Read ↗

Impaired cleavage of preproinsulin signal peptide linked to autosomal-dominant diabetes.Semantic proximity Read ↗

Diabetes-Associated Mutations in Proinsulin Provide a "Molecular Rheostat" of Nascent Foldability.Semantic proximity Read ↗

Role of the Unfolded Protein Response in<i>β</i>Cell Compensation and Failure during DiabetesSemantic proximity Read ↗

Role of Proinsulin Self-Association in Mutant INS Gene-Induced Diabetes of Youth.Semantic proximity Read ↗

Distinct states of proinsulin misfolding in MIDYSemantic proximity Read ↗

Biological behaviors of mutant proinsulin contribute to the phenotypic spectrum of diabetes associated with insulin gene mutations.Semantic proximity Read ↗

An accomplice more than a mere victim: The impact of β-cell ER stress on type 1 diabetes pathogenesisSemantic proximity Read ↗

Endoplasmic reticulum stress, pancreatic β-cell degeneration, and diabetes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.