Article

Role of Proinsulin Self-Association in Mutant <i>INS</i> gene-induced Diabetes of Youth

2019-10-01

Abstract excerpt

Abnormal interactions between misfolded mutant and wild-type (WT) proinsulin in the endoplasmic reticulum (ER) drive the molecular pathogenesis of Mutant- INS -gene induced Diabetes of Youth (MIDY). How these abnormal interactions are initiated remains unknown. Normally, proinsulin-WT dimerizes in the ER. Here, we suggest that the normal proinsulin-proinsulin contact surface, involving the B-chain, contributes to...

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Literature Corpus work: a3fa7bd9-6a86-5f98-aa52-a5219f7c400c
DOI: 10.1101/786970

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