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Article

Phosphorylation of threonine 1736 in the C-terminal tail of integrin β4 contributes to hemidesmosome disassembly.

Molecular biology of the cell - 1 Apr 2012

Frijns Evelyne, Kuikman Ingrid, Litjens Sandy, Raspe Marcel, Jalink Kees, Ports Michael, Wilhelmsen Kevin, Sonnenberg Arnoud

Abstract excerpt

During wound healing, hemidesmome disassembly enables keratinocyte migration and proliferation. Hemidesmosome dynamics are altered downstream of epidermal growth factor (EGF) receptor activation, following the phosphorylation of integrin β4 residues S1356 and S1364, which reduces the interaction with plectin; however, this event is insufficient to drive complete hemidesmome disassembly. In the studies reported...

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Identifiers

PMID: 22357621
DOI: 10.1091/mbc.E11-11-0957
PMCID: PMC3327322

Genes

EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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