Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Keratins Stabilize Hemidesmosomes through Regulation of β4-Integrin Turnover.

The Journal of investigative dermatology - 1 Jun 2015

Seltmann Kristin, Cheng Fang, Wiche Gerhard, Eriksson John E, Magin Thomas M

Abstract excerpt

Epidermal integrity and wound healing depend on remodeling of cell-matrix contacts including hemidesmosomes. Mutations in β4-integrin and plectin lead to severe epidermolysis bullosa (EB). Whether mutations in keratins K5 or K14, which cause EB simplex, also compromise cell-matrix adhesion through altering hemidesmosomal components is not well investigated. In particular, the dependence of β4-integrin endocytosis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Caveolins
Share to Fluorescence Recovery After Photobleaching

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Integrin beta4

Share to Lasers

Share to Plectin

Share to Protein Kinase C-alpha

Share to rab GTP-Binding Proteins

Share to rab5 GTP-Binding Proteins

Source

Identifiers

PMID: 25668239
DOI: 10.1038/jid.2015.46

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Keratins Stabilize Hemidesmosomes through Regulation of β4-Integrin Turnover.PMID 25668239Read ↗

Phosphorylation of threonine 1736 in the C-terminal tail of integrin β4 contributes to hemidesmosome disassembly.Semantic proximity Read ↗

Slac2-b Coordinates Extracellular Vesicle Secretion to Regulate Keratinocyte Adhesion and Migration.Semantic proximity Read ↗

Disease-associated keratin mutations reduce traction forces and compromise adhesion and collective migration.Semantic proximity Read ↗

Keratins and skin disease.Semantic proximity Read ↗

Pathological Mechanisms Involved in Epidermolysis Bullosa Simplex: Current Knowledge and Therapeutic Perspectives.Semantic proximity Read ↗

Plectin gene defects lead to various forms of epidermolysis bullosa simplex.Semantic proximity Read ↗

The Tetraspan Molecule Cd151, a Novel Constituent of Hemidesmosomes, Associates with the Integrin α6β4 and May Regulate the Spatial Organization of HemidesmosomesSemantic proximity Read ↗

Deficiency of the integrin β4 subunit in junctional epidermolysis bullosa with pyloric atresia: consequences for hemidesmosome formation and adhesion propertiesSemantic proximity Read ↗

Keratins as an Inflammation Trigger Point in Epidermolysis Bullosa Simplex.Semantic proximity Read ↗

Hemidesmosomes and focal contact proteins: Functions and cross-talk in keratinocytes, bullous diseases and wound healingSemantic proximity Read ↗

A Skin-depth Analysis of Integrins: Role of the Integrin Network in Health and DiseaseSemantic proximity Read ↗

Keratinocytes display normal proliferation, survival and differentiation in conditional beta4-integrin knockout mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.