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Article

Association of IREB2 and CHRNA3 polymorphisms with airflow obstruction in severe alpha-1 antitrypsin deficiency.

Respiratory research - 22 Feb 2012

Kim Woo Jin, Wood Alice M, Barker Alan F, Brantly Mark L, Campbell Edward J, Eden Edward, McElvaney Gerard, Rennard Stephen I, Sandhaus Robert A, Stocks James M, Stoller James K, Strange Charlie, Turino Gerard, Silverman Edwin K, Stockley Robert A, Demeo Dawn L

Abstract excerpt

BACKGROUND: The development of COPD in subjects with alpha-1 antitrypsin (AAT) deficiency is likely to be influenced by modifier genes. Genome-wide association studies and integrative genomics approaches in COPD have demonstrated significant associations with SNPs in the chromosome 15q region that includes CHRNA3 (cholinergic nicotine receptor alpha3) and IREB2 (iron regulatory binding protein 2).We investigated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22356581
DOI: 10.1186/1465-9921-13-16
PMCID: PMC3306733

Genes

CHRNA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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