Article
Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.
American journal of respiratory and critical care medicine - 1 Oct 2012
Wilk Jemma B, Shrine Nick R G, Loehr Laura R, Zhao Jing Hua, Manichaikul Ani, Lopez Lorna M, Smith Albert Vernon, Heckbert Susan R, Smolonska Joanna, Tang Wenbo, Loth Daan W, Curjuric Ivan, Hui Jennie, Cho Michael H, Latourelle Jeanne C, Henry Amanda P, Aldrich Melinda, Bakke Per, Beaty Terri H, Bentley Amy R, Borecki Ingrid B, Brusselle Guy G, Burkart Kristin M, Chen Ting-hsu, Couper David, Crapo James D, Davies Gail, Dupuis Josée, Franceschini Nora, Gulsvik Amund, Hancock Dana B, Harris Tamara B, Hofman Albert, Imboden Medea, James Alan L, Khaw Kay-Tee, Lahousse Lies, Launer Lenore J, Litonjua Augusto, Liu Yongmei, Lohman Kurt K, Lomas David A, Lumley Thomas, Marciante Kristin D, McArdle Wendy L, Meibohm Bernd, Morrison Alanna C, Musk Arthur W, Myers Richard H, North Kari E, Postma Dirkje S, Psaty Bruce M, Rich Stephen S, Rivadeneira Fernando, Rochat Thierry, Rotter Jerome I, Soler Artigas María, Starr John M, Uitterlinden André G, Wareham Nicholas J, Wijmenga Cisca, Zanen Pieter, Province Michael A, Silverman Edwin K, Deary Ian J, Palmer Lyle J, Cassano Patricia A, Gudnason Vilmundur, Barr R Graham, Loos Ruth J F, Strachan David P, London Stephanie J, Boezen H Marike, Probst-Hensch Nicole, Gharib Sina A, Hall Ian P, O'Connor George T, Tobin Martin D, Stricker Bruno H
Abstract excerpt
RATIONALE: Genome-wide association studies (GWAS) have identified loci influencing lung function, but fewer genes influencing chronic obstructive pulmonary disease (COPD) are known. OBJECTIVES: Perform meta-analyses of GWAS for airflow obstruction, a key pathophysiologic characteristic of COPD assessed by spirometry, in population-based cohorts examining all participants, ever smokers, never smokers, asthma-free...
Read the complete abstract on PubMed