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Article

Serine protease Per a 10 from Periplaneta americana bias dendritic cells towards type 2 by upregulating CD86 and low IL-12 secretions.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Mar 2012

Goel C, Govindaraj D, Singh B P, Farooque A, Kalra N, Arora N

Abstract excerpt

BACKGROUND: Serine protease activity of Per a 10 from Periplaneta americana induces airway inflammation and systemic Th2 response towards self and bystander allergen. OBJECTIVE: In the present study the effect of proteolytic activity of Per a 10 allergen on dendritic cells (DCs) polarization and consequent T cell response was investigated. METHODS: Non-atopic subjects with no family history of asthma/allergy were...

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PMID: 22356142
DOI: 10.1111/j.1365-2222.2011.03937.x

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