Article
The Malassezia sympodialis allergen Mala s 11 induces human dendritic cell maturation, in contrast to its human homologue manganese superoxide dismutase.
International archives of allergy and immunology - 1 Jan 2007
Vilhelmsson Monica, Johansson Catharina, Jacobsson-Ekman Gunilla, Crameri Reto, Zargari Arezou, Scheynius Annika
Abstract excerpt
BACKGROUND: Recently, we identified a major Malassezia sympodialis allergen, Mala s 11, which displays a high degree of DNA sequence homology to human manganese superoxide dismutase (hMnSOD). In atopic eczema patients sensitized to M. sympodialis, hMnSOD can elicit eczematous reactions and positive skin prick tests, suggesting cross- reactivity to Mala s 11 based on molecular mimicry. The objective of the current...
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