Article
IL-10 controls dendritic cell-induced T-cell reactivation in the skin to limit contact hypersensitivity.
The Journal of allergy and clinical immunology - 1 Jan 2012
Girard-Madoux Mathilde J H, Kel Junda M, Reizis Boris, Clausen Björn E
Abstract excerpt
BACKGROUND: IL-10 is a pleiotropic cytokine and potent negative regulator of both innate and adaptive immune responses. Consequently, IL-10-deficient (IL-10(-/-)) mice have enhanced contact hypersensitivity (CHS) to topical hapten. OBJECTIVE: Although the importance of IL-10 production by (regulatory) T cells and Langerhans cells in regulating CHS has been established by cell type-specific il-10 gene targeting,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.