Expression of a membrane protease enhances presentation of endogenous antigens to MHC class I-restricted T lymphocytes.

doi:10.1016/0092-8674(92)90392-p

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Article

Expression of a membrane protease enhances presentation of endogenous antigens to MHC class I-restricted T lymphocytes.

Cell - 11 Dec 1992

Eisenlohr L C, Bacik I, Bennink J R, Bernstein K, Yewdell J W

Abstract excerpt

We find that expression of the membrane dipeptidyl carboxypeptidase angiotensin-converting enzyme (ACE) enhances presentation of certain endogenously synthesized peptides to major histocompatibility complex (MHC) class I-restricted cytotoxic T lymphocytes. ACE appears to function only in an intracellular secretory compartment of antigen-presenting cells. ACE-enhanced antigen presentation requires the expression...

Topics

ATP Binding Cassette Transporter, Subfamily B, Member 2
ATP Binding Cassette Transporter, Subfamily B, Member 3
ATP-Binding Cassette Transporters
Amino Acid Sequence
Animals
Antigen-Presenting Cells
Carrier Proteins
Cell Line
Endopeptidases
Endoplasmic Reticulum

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Histocompatibility Antigens Class II

Humans

Membrane Proteins

Molecular Sequence Data

Mutation

Peptidyl-Dipeptidase A

T-Lymphocytes

Source

Open in PubMed

Identifiers

PMID: 1333889
DOI: 10.1016/0092-8674(92)90392-p

Genes

ACE
TAP1
TAP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1333889-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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