Article
Aberrant function of peripheral blood myeloid and plasmacytoid dendritic cells in atopic dermatitis patients.
The Journal of allergy and clinical immunology - 1 Nov 2008
Lebre M Cristina, van Capel Toni M M, Bos Jan D, Knol Edward F, Kapsenberg Martien L, de Jong Esther C
Abstract excerpt
BACKGROUND: Dendritic cells (DCs) can act both as innate cells in host defense and as antigen-presenting cells for naive T cells in adaptive immunity. These functions, among others, are determined by the level of production of particular cytokines. Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by an initial phase predominated by T(H)2 cytokines that switches into a second, more...
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