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Article

In Vivo Aggregation of β‐Amyloid Peptide Variants

1 Oct 1998

Abstract excerpt

Transgenic Caenorhabditis elegans animals have been engineered to express wild-type and single-amino acid variants of a long form of human beta-amyloid peptide (A beta 1-42). These animals express high levels (approximately 300 ng of A beta/mg of total protein) of apparently full-length peptide, as determined by quantitative immunoblot. Expression of wild-type A beta in these animals leads to rapid production of...

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Identifiers

PMID: 9751195
DOI: 10.1046/j.1471-4159.1998.71041616.x

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