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Article

In vivo Evaluation of a Newly Synthesized Acetylcholinesterase Inhibitor in a Transgenic Drosophila Model of Alzheimer’s Disease

30 Jun 2021

Abstract excerpt

Alzheimer’s disease is a neurodegenerative disease characterized by disrupted memory, learning functions, reduced life expectancy, and locomotor dysfunction, as a result of the accumulation and aggregation of amyloid peptides that cause neuronal damage in neuronal circuits. In the current study, we exploited a transgenicDrosophila melanogasterline, expressing amyloid-β peptides to investigate the efficacy of a...

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PMID: 34276297
DOI: 10.3389/fnins.2021.691222

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