Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Testing the Therapeutic Potential of Doxycycline in a Drosophila melanogaster Model of Alzheimer Disease

14 Oct 2011

Abstract excerpt

Therapies for Alzheimer disease that reduce the production of pathogenic amyloid β (Aβ) peptides have been associated with a range of unwanted effects. For this reason, alternative strategies that promote the clearance of the peptide by preventing its aggregation and deposition in the brain have been favored. In this context we have studied doxycycline, a member of the tetracycline family of antibiotics that has...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Cholinesterase and Neurodegenerative Diseases
Share to Computational Drug Discovery Methods

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 21998304
DOI: 10.1074/jbc.m111.274548

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Testing the Therapeutic Potential of Doxycycline in a Drosophila melanogaster Model of Alzheimer DiseasePMID 21998304Read ↗

The Anti-Amyloidogenic Action of Doxycycline: A Molecular Dynamics Study on the Interaction with Aβ42Semantic proximity Read ↗

Doxycycline: An essential tool for Alzheimer’s diseaseSemantic proximity Read ↗

Ageing Increases Vulnerability to Aβ42 Toxicity in DrosophilaSemantic proximity Read ↗

Curcumin promotes A-beta fibrillation and reduces neurotoxicity in transgenic Drosophila.Semantic proximity Read ↗

Tetracycline and its analogues protect Caenorhabditis elegans from β amyloid-induced toxicity by targeting oligomersSemantic proximity Read ↗

Doxycycline disrupts transthyretin amyloid: evidence from studies in a FAP transgenic mice model.Semantic proximity Read ↗

In vivo Evaluation of a Newly Synthesized Acetylcholinesterase Inhibitor in a Transgenic Drosophila Model of Alzheimer’s DiseaseSemantic proximity Read ↗

Alleviatory effects of Danshen, Salvianolic acid A and Salvianolic acid B on PC12 neuronal cells and <i>Drosophila melanogaster</i> model of Alzheimer’s diseaseSemantic proximity Read ↗

Alzheimer's disease drug discovery: in vivo screening using Caenorhabditis elegans as a model for β-amyloid peptide-induced toxicitySemantic proximity Read ↗

Misfolded transthyretin causes behavioral changes in a Drosophila model for transthyretin-associated amyloidosis.Semantic proximity Read ↗

Complete phenotypic recovery of an Alzheimer's disease model by a quinone-tryptophan hybrid aggregation inhibitor.Semantic proximity Read ↗

Efficient imaging of amyloid deposits in Drosophila models of human amyloidoses.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.