Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Generation and characterization of transforming variants of the lck tyrosine protein kinase.

Oncogene - 1 Jun 1992

Adler H T, Sefton B M

Abstract excerpt

p56lck, a tyrosine protein kinase of the src family, is overexpressed in two murine thymoma cell lines, LSTRA and Thy19, as a result of the integration of Moloney murine leukemia virus sequences upstream of the lck gene. The majority of the p56lck in these cell lines is translated from a hybrid mRNA comprised of the 5' untranslated region of the murine leukemia virus env mRNA and lck coding sequences. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Base Sequence
Share to Cell Line

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Molecular Sequence Data

Share to Polymerase Chain Reaction

Share to RNA, Messenger

Source

Identifiers

PMID: 1594248

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Generation and characterization of transforming variants of the lck tyrosine protein kinase.PMID 1594248Read ↗

Functional analysis of the SH2 and SH3 domains of the lck tyrosine protein kinase.Semantic proximity Read ↗

ALK-activating homologous mutations in LTK induce cellular transformation.Semantic proximity Read ↗

Enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck.Semantic proximity Read ↗

Activation of p56lck through mutation of a regulatory carboxy-terminal tyrosine residue requires intact sites of autophosphorylation and myristylation.Semantic proximity Read ↗

Expression of the T-Cell–Specific Tyrosine Kinase Lck in Normal B-1 Cells and in Chronic Lymphocytic Leukemia B CellsSemantic proximity Read ↗

A new strategy to produce active human Src from bacteria for biochemical study of its regulation.Semantic proximity Read ↗

Mutational activation of pp60(c-src) leads to a tumorigenic phenotype in a preneoplastic Syrian hamster embryo cell line.Semantic proximity Read ↗

Generation of Eμ-PKCβII transgenic mice for the study of chronic lymphocytic leukaemia (CLL)Semantic proximity Read ↗

Role of the autophosphorylation site on the biological function of pp56lck.Semantic proximity Read ↗

Parallel analysis of v-Src mutant protein function using reverse transfection cell arrays.Semantic proximity Read ↗

Phosphorylation of Src mutants at Tyr 527 in fibroblasts does not correlate with in vitro phosphorylation by CSK.Semantic proximity Read ↗

Regulation of T cell receptor signaling by a src family protein-tyrosine kinase (p59fyn).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.