Article
Generation and characterization of transforming variants of the lck tyrosine protein kinase.
Oncogene - 1 Jun 1992
Adler H T, Sefton B M
Abstract excerpt
p56lck, a tyrosine protein kinase of the src family, is overexpressed in two murine thymoma cell lines, LSTRA and Thy19, as a result of the integration of Moloney murine leukemia virus sequences upstream of the lck gene. The majority of the p56lck in these cell lines is translated from a hybrid m...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Blotting, Western
- Cell Line
- Gene Expression
- Genetic Variation
- Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
- Mice
- Mice, Inbred BALB C
- Molecular Sequence Data
- Oligodeoxyribonucleotides
- Oncogenes
- Peptide Mapping
- Plasmids
- Polymerase Chain Reaction
- Protein-Tyrosine Kinases
- RNA, Messenger